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Using two separate drugs to lose weight naturally can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err to the side of caution and allow the FDA do its job and demand some research be done so that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on the medications. Researchers found out that participants taking this drug for a year, dropped a few pounds within one month and have kept the load off throughout the 56 weeks in the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, which can make them more potent and safer. Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure levels and heart rate, and really should not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. From a psychiatric viewpoint, evidence points too the ordinary neural mechanism for goal-directed behavior continues to be hijacked through the addiction, and malfunctions such that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus along with the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).